In the conditions of the Republic of Belarus there was determined the influence of nutritional medium composition on pathogenic properties of leptospirosis bacteria, by an example of 6 pathogenic strains: Leptospira pomona; Leptospira tarassovi; Leptospira grippothyphosa; Leptospira icterrohaemorragia; Leptospira conicola; Leptospira hardjo. During the study there were used the following media: serum-supplemented vitaminized medium on the basis of buck serum; serum-supplemented medium with a growth factor; serum-supplemented vitaminized medium with antlbody biosynthesis growth factor; semisynthetic Russel's medium. According to the results of realized studies there was developed a correlation between terms of leptospirosis bacteria survivability in laboratory animals depending on cultivation medium. In course of the study there were analyzed terms of Leptospira persistence in guinea pigs.

The research was realized by an example on 30 chickens aged 1, 10, 20, 30 60-days old, and 10 hens: 4-months, one-year-old and 2-year-old in the conditions of the Republic of Belarus. All poultry stock was maintained in the conditions of industrial production at the Gorodokskaya Poultry Farm of Vitebsk region (Belarus). As a result of the study there was revealed a certain pattern of variation of a quantity of active forms of enzymes in organs chickens of different age. Application of histochemical methods made it possible to reveal different levels of metabolic processes in cellular elements of thyroid gland, which demonstrated the habit of formation and functioning of the organ at different stages of postnatal ontogenesis in hens. Coefficients of acid phosphatase activity in thyrocytes of thyroid gland of hens and indexes of alkaline phosphatase activity in secretion forming cells were analyzed. | Исследование провели на 30 цыплятах в возрасте 1-, 10-, 20-, 30- 60-дней, и 10 курах: 4-месячные молодки, годовалые и 2-летние особи. Все поголовье птицы содержалось в условиях промышленного производства на Городокской птицефабрике Витебской области. В результаты исследований установлена определенная закономерность изменения количества активных форм ферментов в органах птиц разного возраста. Использование гистохимических методов позволило выявить разные уровни метаболических процессов в клеточных элементах щитовидной железы, которые демонстрируют характер становления и функционирования органа на разных этапах постнатального онтогенеза кур. В табличной форме представлены коэффициенты активности кислой фосфатазы в тироцитах щитовидной железы кур и показатели активности щелочной фосфатазы в секретообразующих клетках.

In the conditions of the Republic of Belarus there was realized a morphological analysis of pectoral and leg muscles of broiler chickens of cross Cobb-500 in the process of administration of metabolic activator Catosal. Research results showed the positive influence of catosal on the myogenesis: diameter of muscle fiber, the amount of bigger diameter muscles fibers in the first order strand and homogeneity of muscle strands. Under the influence of Catosal preparation there was stated the increasing of the amount of muscle tissue in pectoral and leg parts of chicken carcass. | Приведены данные морфологических исследований грудных и ножных мышц цыплят-бройлеров кросса Кобб-500 при применении активатора метаболизма катозал. Установлено, что катозал активизирует миогенез за счет увеличения диаметра мышечных волокон, содержания в пучках первого порядка мышечных волокон большей толщины, а также большей однородности мышечных пусков. Под действием препарата происходит увеличение содержания мышечной ткани как в грудной части тушки, так и в окороках.

In the conditions of the Republic of Belarus there was realized a comparative studying of immune reactivity of broiler chickens immunized against Marek's disease by means of vaccines of Russian production. In course of the study it was established, that in broiler chickens vaccinated against Marek's disease (by means of cultural dry viral vaccine on the basis a virus of herpes of turkeys FS-126 and by liquid bivalent cultural virus vaccine Bimarek on the basis of strains of a herpes virus of turkeys and a herpes virus of hens) the revealed morphological changes in immune system organs of did not essentially differ and testified to the development of intense postvaccinal immunity. Economic efficiency of immunization of broiler chicken against Marek's disease under production conditions made 4,87 and 2,94 Belarusian roubles per 1 rouble of expenses, respectively. | Целью исследования явилось сравнительное изучение иммунной реактивности организма цыплят-бройлеров, иммунизированных против болезни Марека вакцинами российского производства. В ходе исследований установлено, что у цыплят-бройлеров, вакцинированных против болезни Марека культуральной сухой вирусвакциной из вируса герпеса индеек ФС-126 и жидкой бивалентной культуральной вирусвакциной Бимарек из штаммов вируса герпеса индеек и вируса герпеса кур выявленные морфологические изменения в органах иммунной системы существенно не отличаются и свидетельствуют о выработке напряженного поствакцинального иммунитета. Экономическая эффективность иммунизации цыплят против болезни Марека в производственных условиях составляет 4,87 и 2,94 рубля на 1 рубль затрат соответственно.

Morphological and biological characteristic of isospora and eimeria was realized in the conditions of the Republic of Belarus on the basis of carried out measurements and experimental infection minks (Mustela). Research results showed, that in Belarus at mink breeding farm holdings there were determined four species of eimeria and isospores, one of which I. eversmanni - is registered by researchers from the Vitebsk State Academy of Agriculture in the Republic for the first time. The most widespread species is Е. vison (57,03%) was found out in all analyzed 24 fur breeding farms. Species composition of eimeria and isospores did not depend on a sex and typical coat pattern of minks, as well as on a geographical location area of an analyzed farm. Some distinctions in species composition of the intestinal protozoa were observed at minks of different age. Of all analyzed species the most pathogenic proved to be Е. vison and I. laidlawi which in case of infectioning caused animal mortality. | Дана морфологическая и биологическая характеристика изоспор и эймерий на основании проведенной микрометрии и экспериментального заражения норок. Таким образом, по результатам проведенных нами исследований следует отметить, что в Республике Беларусь у норок, разводимых в хозяйствах, установлено четыре вида эймерий и изоспор, один из которых - I. eversmanni - зарегистрирован нами в республике впервые. Самым распространенным видом является Е. vison (57,03%), обнаруженный во всех обследованных нами 24-х зверохозяйствах. Видовой состав эймерий и изоспор не зависит от пола и типовой окраски норок, а также от географического месторасположения хозяйства. Некоторые различия в видовом составе кишечных простейших наблюдались у норок разного возраста. Из отмеченных видов наиболее патогенными являются Е. vison и I. laidlawi, вызывающие при заражении падеж зверей.

Despite of presence of a wide choice of antihelminthics, in the Republic of Belarus it is still a real problem of development of preparations that provide long-term treatment and preventive maintenance efficiency against helminthosis. At the same time, helminthes and anthelminthics render the immunosuppression action. The solution of this problem can be a combined application of antihelminthics and adjuvants. There were proposed preparations Albepolis and Averpolis. Their application made it possible not only to release an organism of animals from parasites, but also to correct the state of immune system. The obtained research data confirm the available data about the immunosuppression action of parasites on an organism of animals. There was also is noted the immunosuppression action of Albendazol and Aversektin C in therapeutic doses. Albendazol possess a wide spectrum of action against trematodes, nematodes, cestodes. It interrupts the metabolism, oppresses fumarate reductase activity and adenosine triphosphate synthesis of a parasite. It proved to be low-toxic for homoiothermal animals. Albendazol rendered positove influence on growth, development and increase of cattle productivity.

In the conditions of the Republic of Belarus there were presented the results of a veterinary and sanitary assessment and bacteriological investigation of sheep slaughter products, which showed meat serviceability for consumption after application of Triclafen suspension. Application Triclafen suspension did not render negative influence on an organism of animals. It was proved by organoleptic and laboratory research of meat of slaughter animals of experimental and control groups. The meat obtained from healthy sheep which were administrated the suspension in accordance with microbiological indicators proved to be of good quality and corresponded to the established norms (Sanitary regulations and standards 11 - 63 Republic of Belarus 98): it had the general bacterial content within admissible limits and did not contain agents of anthropozoonosts, alimentary toxicosis and toxinfections and it can be sold without any restrictions.

In the conditions of the Republic of Belarus there was realized a complex of studies of quality swine slaughter products against the background of combine applications of the albuminous-vitamin-mineral additive Immovit and an extract of hill-growing saltwort for the preventive maintenance and treatment of a toxic dystrophy of liver. Research results showed the analysed preparations did not render negative influence on quality and safety of produced meat products. Against the background of application of the albuminous-vitamin-mineral additive Immovit in combination with an extract of hill-growing saltwort there was stated the improvement of swine slaughter product quality. In products from the animals which were administrated with a complex of examined preparations there was stated an optimized moisture content, the increasing of a relative biological value of a product (101,3-103,8%), and according to the indexes of bacterial safety the experimental pork considerably surpassed the meat indexes from animals of control groups. At the same time, in slaughter animal products of control groups there were revealed coliform bacillus bacteria.

In the conditions of the Republic of Belarus there were determined the parameters of acute and subacute toxicological characteristics of the developed in the Vitebsk State Academy of Veterinary Medicine anthelmintic preparations of durable action Febolvetum-О for control of sheep strongylatosis and Febolvetum for control of strongylatosis of cattle young stock. Data on determination of toxicological parameters of the prolonged action bolus were presented. Research results showed that the preparations did not render negative influence on laboratory animals (white mice). According to the parameters of acute oral toxicity the Febolvetum was qualify as the third hazard class. In accordance with the results of study of subacute toxicity parameters of the preparations, it was concluded, that in the conditions of free feeding of Febolvetum boluse in combination with forages in course of 30 days in doses of 200 mg/kg; 150 mg/kg; 100 mg/kg of body weight in animals there were found no signs of intoxication; there were not stated any is not fixed deviations in physiological state; and were stated no mice death.

In the conditions of the Republic of Belarus there was studied the activity of hepatic specific enzymes of blood serum of bull calves of black-and-white breed in course of application of various doses of zinc-containing preparations. Application of zinc-containing preparations led to multidirectional change of activity of hepatic specific serum enzymes. Application of Zinkovet preparation in dose of 1,8 g/100 kg of live weight made it possible to essentially grade the indexes of hepatic tissue affect. In the experimental group at animals there was marked the lowering in activity alanine-aminotransferase, serum glutamic oxalacetic transaminase and gamma-glutamyl transpeptidase. At the same time, there was noted the increasing of zinc-containing enzymes activity (sorbitol dehydrogenase and glutamate dehydrogenase). All these processes were caused by zinc inclusion into the metabolic process.