ACTH-cells and adrenal cortex in adult rats treated with a single dose of hydrocortisone during the neonatal or juvenile period of development
1987
Hristic, M. | Pantic, V. | Kalafatic, D. | Markovic, V. (Institute for Biological Research "Sinisa Stankovic", Beograd (Yugoslavia))
This is a study of the ACTH-cells of the anterior pituitary gland and the adrenal cortex in three-month-old rats treated with a single dose of hydrocortisone during the neonatal, the early of late juvenile period of development. The ultrastructural properties of ACTH-cells showed signs of retarded release of hormones in all of the treated animals, being more pronounced if the animals were treated during the juvenile period. The incorporation of 3H-hydrocortisone in the cells of the anterior pituitary gland of rats treated during the juvenile period was more intensive and the number of hypertrophied ACTH-cells in neonatally treated rats increased, on the basis of which it can be concluded that the regenerative ability is more pronounced if a longer period of time has passed after treatment with the tested steroid.
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