`Winged' hyper-mutated epitopic mimetics of VP1 (135-146): a novel molecular design for broad-spectrum, multivalent synthetic vaccine against the foot-and-mouth disease virus serotype A
1996
Deocaris, C.C. | Nato, A.Q. Jr. | Nazarea, A.D. | Mateo, A.G. (Philippine Nuclear Research Inst., Commonwealth Ave., Diliman, 1101 Quezon City (Philippines))
An assemblage of synthetic vaccines are engineered against continuously epitopic areas of the foot-and-mouth disease virus (FMDV) serotype A comprising residues flanking the RGD loop, belonging to a family important structural motifs identified with integrin-binding proteins, of the immunodominant epitope VP1 or Antigen site A. In the paper, the importance of salient molecular endowments of the synthetic vaccines are emphasized: a.) a cocktail or sequence hyper-mutations for host recognition of known and possibly unknown intratypic ligand variabilities, (b) optimal utilization of previously mapped viral T and B cell epitopes for antigen presentation and, c.) attachment of a potent non-viral T cell epitope as `wing' to enhance cellular response. This molecular design for novel anti-viral immunogen is deemed to elicit strong neutralizing antibody repertoire and solid cell-mediated protection against FMDV challenge in economically important livestock
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