Effect of tomato pomaces on hypercholesterolemia and colon carcinogenesis in rats
1999
Bobek, P. | Galbavy, S. (Vyskumny Ustav Vyzivy, Bratislava (Slovak Republic))
The effect of dietary cellulose (5 or 15%) and dried powdered tomato pomace (15%) on the development of hypercholesterolemia and colon carcinoma was studied in male Wistar rats. The animals were fed with a diet containing 0.3% of cholesterol and recieved 12 doses of dimethylhydrazine (20 mg/kg) subcutaneously in one-week intervals. Fiber content in tomato peels was 47.2 g/100 g of dry matter, 10.3% of which was in water-soluble form. Tomato pomace in the diet caused a reduction of serum cholesterol level by 30% during 14 weeks after dimethylhydrazine application while the cellulose content in the diet had no significant effect. Liver content of conjugated dienes was reduced by 40% and the activities of superoxide dismutase and glutathione peroxidase in liver increased twofold by tomato pomaces. Compared to the diet containing 5% cellulose, tomato peels diet caused a significant reduction of the average occurrence of pre-neoplastic lesions (aberrant crypt foci) in the colon. Similarly, tomato peels diet caused a reduction of incidence of the dominant type of tumors (tumour foci characterised as highly differentiated adenocarcinoma with the penetration of tumour cells through lamina basalis) by 50% as well as the total volume of tumours. However, the effect for two last mentioned parameters was on the limit of statistical significancy
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