Light and electron microscopic studies on the effect of tenoxicam on the stomach of the mouse
2002
Yousif, W.B. (Alexandria Univ. (Egypt). Dept. of Zoology)
The effects of new nonsteroidal anti-inflammatory drug (NSAID), Tenoxicam (Epicotal), on the light and electron microscopy of the stomach of the mice were studied. Administration of daily high therapeutic dose (0.12 mg kg-1 body weight) for 30 days showed obvious pathologic changes. Extensive light microscopic changes are noticed including dilation and congestion of blood vessels and blood capillaries, a decrease of the amount of lymphoid cells in the submucosa and the lamina propria and obvious changes of the smooth muscle fibers of the stomach. Significant morphological changes in gastric gland were revealed by electron microscopy. Several unusual structural features are observed in oxyntic cells including increase in the heterochromatin in nucleus, some nuclei contain dense heterochromatin, destruction of nuclear membrane, decreased and dense mitochondria, hypertrophied golgi apparatus, decrease of tubulovesicles and myofibrils in the apical cytoplasm, fragmentation of rough endoplasmic reticulum, increase of the ribosomes and vacuolation of the connective tissue in between the blood capillary and the base of oxyntic cell. Peptic cells showed no apparent changes. In addition, the administration of high therapeutic dose of the Tenoxicam for 30 days exhibited obvious histological changes in cardiac muscles including severe congestion and dilatation of blood vessels and indentation of the muscle fibers.
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