Correlations between milk production and kinetic variables in milk of cephalothin administered to lactating goats
Rule, R.(Commission of Scientific Research of the Province of Buenos Aires (Argentina))E-mail:robertorule@yahoo.com.ar | Cordiviola, C.(La Plata Univ., (Argentina). Dept. of Introduction to Animal Production) | Vita, M.(La Plata Univ., (Argentina). Dept. of Pharmacology) | Lacchini, R.(La Plata Univ., (Argentina). Dept. of Introduction to Animal Production)
The aim of the present study was to correlate the milk production and the kinetic variables of cephalothin in goat milk. Twenty healthy creole lactating goats were administered cephalothin intravenously (20 mg/kg b.w.). Milk samples were collected at 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 8.0 and 12.0 hours postadministration of the antibiotic. Cephalothin concentrations were measured in milk samples by HPLC. The results of the kinetic variables of cephalothin in milk were as follows: AUC=5.4+/-1.6 microg/mL/h; Cmax=1.1+/-0.3 microg/mL and tmax=1.7+/-0.1 h. The correlation coefficients AUC-milk production, Cmax-milk production and tmax-milk production were as follows: 0.602 (P less than 0.01), 0.596 (P less than 0.01) and 0.398 (P less than 0.1), respectively. In conclusion, the maximum concentrations in milk and the time to reach them are in fact related to the volume of milk produced by the goats.
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