Replacement of the in vivo Bioassay for Erythropoietin with the in vitro Bioassay
2003
Paik,S.H. | Kim, J.M. | Kwon, G.S. | Park, S.Y. | Huh, J.W. (Central Research Center, Green Cross R D Corporation, Yong-in, Republic of Korea)
In vivo bioassays for biological medicines have been considered final resort to unequivocally assess the biological activities for them because there are some cases in which the biological activities obtained from in vivo bioassay and in vitro bioassay quite differ each other. The in vivo biological activity of EPO depends on its sialic acid contents which confer microheterogeneity-isoforms to this protein.
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