On-line Monitoring and Control of Substrate Concentrations in Biological Processes by Flow Injection Analysis Systems
Rhee, J.I.(Chonnam National University, Gwangju, Republic of Korea)E-mail:jirhee@chonnam.ac.kr | Ritzka, Adnan;Scheper, Thomas(University of Hannover, Hannover, Germany)
Concentrations of substrates, glucose, and ammionia in biological processes have been on-line monitored by using glucose-flow injection (FIA) and ammonia-FIA systems. Based on the on-line monitored data the concentrations of substrates have been controlled by an on-off controller, a PID controller, and a neural network (NN) based controller. A simulation program has been developed to test the control quality of each controller and to estimate the control parameters. The on-off controller often produced high oscillations at the set point due to its low robustness.
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