Study on the quantitation of moxidectin by fluoroscence derivatization and it's residual after subcutaneously injection in pigs
Jang, B.S.;Lim, J.H.;Park, B.K.;Yun, H.I.(Chungnam National University, Daejeon, Republic of Korea)E-mail:hiyun@cnu.ac.kr | Kim, M.K.(Seoul National University, Seoul, Republic of Korea)
We established a new method to analyze moxidectin using high performance liquid chromatography(HPLC) with fluorescence derivatization in order to obtain its residual profiles in biological samples. Recovery of moxidectin in tissue was 62% at 10 ppb. Average detection reproducibility in terms of coefficience variation was 4.47% at 0.32 to 10 ppb. Residual of moxidectin was studied in 44 Yorkshire-Landrace mixed bred male pigs administered subcutaneously 0, 200, or 800 ㎍/kg body weight (BW) Residual profiles of moxdectin in blood, muscle, liver, kidney and fat of pigs were described. The concentration of the moxidectin in liver after administration of moxidectin was the highest among the tissues examined.
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