STAT mRNA kinetics in the central nervous system during autoimmune encephalomyelitis in lewis rats
Jee, Y.H.;Hwang, I.S.;Shin, T.K.;Moon, C.J.;Lim, Y.K.;Yeo, I.K.(Cheju National University, Jeju, Republic of Korea)E-mail:yhjee@cheju.ac.kr | Son, H.Y.(Chungnam National University, Daejeon, Republic of Korea)
To elucidate the molecular mechanisms of autoimmune inflammation in the central nervous system, we examined the expression and localization of STAT1, STAT3, STAT4 and STAT6 molecules during experimental autoimmune encephalomyelitis (EAE) by competitive PCR. In the present study, we quantitated IL-4 and IL-12 p40 mRNA by competitive PCR in the CNS during EAE. IL-4 mRNA was found at early and peak stages. On the other hand, the IL-12 p40 mRNA level reached maximal levels at the peak stage and still found at the recovery stage of the disease.
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