The relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in mesangial cells
Park, S.H.;Heo, J.S.;Han, H.J.(Chonnam National University, Gwangju, Republic of Korea)E-mail:hjhan@chonnam.ac.kr | Kang, C.W.(Chonbuk National University, Jeonju, Republic of Korea)
The proliferation of mesangial cells has been associated with the development of diabetic nephropathy. The cell proliferation has been regulated by diverse growth factors. Among them, insulin like growth factors(IGFs) are also involved in the pathogenesis of diabetic nephropathy. However, it is not yet known about the effect of high glucose on IGF-I and IGF-Ⅱ secretion and the relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in the mesangial cells.
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