cDNA Cloning of Farnesoic Acid-Induced Genes in Candida albicans by Differential Display Analysis
2005
Chung, S.C. (Seoul National University, Seoul, Republic of Korea) | Lee, J.Y. (Seoul National University, Seoul, Republic of Korea) | Oh, K.B. (Seoul National University, Seoul, Republic of Korea), E-mail: [email protected]
The yeast Candida albicans has a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: a budding yeast form and a multicellular invasive filamentous form. This ability has been postulated to contribute to the virulence of this organism. Previously, we reported that the yeast-to-hypha transition in this organism is suppressed by farnesoic acid, a morphogenic autoregulatory substance that accumulates in the medium as the cells proliferate.
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