Inhibition of human breast carcinoma by BLC (Sargassum fulvellum) and BLC/HEN Egg in vitro and in vivo
2005
Jo, E.H. (Seoul National University, Seoul, Republic of Korea) | Park, H.K. (Sam-Hwa Farm, Yeongju, Republic of Korea) | Cho, S.D. (Seoul National University, Seoul, Republic of Korea) | Ahn, N.S. (Seoul National University, Seoul, Republic of Korea) | Jung, J.W. (Seoul National University, Seoul, Republic of Korea) | Yang, S.R. (Seoul National University, Seoul, Republic of Korea) | Park, J.S. (Seoul National University, Seoul, Republic of Korea) | Hwang, J.W. (Seoul National University, Seoul, Republic of Korea) | Lee, S.H. (Seoul National University, Seoul, Republic of Korea) | Park, J.R. (Seoul National University, Seoul, Republic of Korea) | Kim, S.J. (Seoul National University, Seoul, Republic of Korea) | Lee, Y.S. (Seoul National University, Seoul, Republic of Korea) | Kang, K.S. (Seoul National University, Seoul, Republic of Korea), E-mail: kangpub@snu.ac.kr
Much of the interest on the chemopreventive properties of herbs and plants has been raised, whereas little is regarding to anti-tumor effect of farming and aquatic products. In the present study, the anti-tumor effect of hot-water extract of a seaweed, BLC (Sargassum fulvellum) and BLC/HEN egg was investigated using MCF-7 cells in vitro and in vivo systems. We found that the BLC extract and BLC/HEN egg inhibited cell proliferation in a dose-dependent manner, which might be mediated through up-regulation of p53. Furthermore, this test compound can directly induce apoptosis in MCF-7 cells, which might be mediated through up-regulation of a pro-apoptotic Bax protein and down-regulation of a anti-apoptotic Bcl-2 protein, not by immune system.
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