Comparison of immune responses of dogs and guinea pigs inoculated with inactivated canine coronavirus vaccines
2005
An, D.J. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea) | Kim, B.H. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea), E-mail: kimbh@nvrqs.go.kr | Jung, B.Y. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea) | Yi, C.H. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea) | Jeon, W.J. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea) | Lee, P.S. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea) | Chung, G.S. (National Veterinary Research and Quarantine Service, MAF, Anyang, Republic of Korea)
Canine coronavirus (CCV) causes a mild gastroenteritis in dogs. The virus is highly contagious. Although the virus was isolated more than thirty years ago, canine coronavirus infection continues to be a widespread problem. Mixed infections with both CCV and canine parvovirus (CPV) are common. Four kinds of commercial killed CCV vaccines are available in Korea. All the commercial vaccines should pass the National Assay for Veterinary Biologicals prior to release. For the potency test of CCV vaccine, it is necessary to use CCV antibody free dogs. The test requires not only kennels but high cost. To develop easy, efficient and economic potency test method for killed CCV vaccine using laboratory animals, a series of experiments with rabbits and guinea pigs were carried out in this study.
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