Anti-oxidant Activities and Anti-inflammatory Effects on Artemisia scoparia
2006
Yoon, W.J. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Lee, J.A. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Kim, J.Y. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Oh, D.J. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Jung, Y.H. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Lee, W.J. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Park, S.Y. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea), E-mail: user111@jejuhidi.or.kr
We investigated the antioxidant activities such as DPPH radical scavenging capacity, xanthine oxidase inhibitory activity, and superoxide radical scavenging capacity of the aqueous EtOH extract and its solvent fractions of Artemisia scoparia. The ethylacetate fraction showed high antioxidant activity, compared to positive controls such as ascorbic acid, butylated hydroxy anisole (BHA), trolox, and allopurinol in these assay systems. Moreover, we examined the inhibitory effect of solvent fractions of A. scoparia on the production of pro-inflammatory factors that the nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE₂) production activated with LPS(1 ㎍/㎖) in murine macrophage cell line RAW264.7.
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