Inhibitory Effect of Bacopa monniera on morphine Induced Pharmacological Effects in Mice
2007
Sumathi, T. (University of Madras, Taramani Campus, Tamil Nadu, India), E-mail: sumati_doctor@yahoo.co.in | Balakrishna, K. (Central Research Institute for Siddha, Tamil Nadu, India) | Veluchamy, G. (Central Research Institute for Siddha, Tamil Nadu, India) | Niranjali Devaraj, S. (University of Madras, Guindy Campus, Chennai, India)
The effects of the alcoholic extract of Bacopa monniera (BMA) on morphine-induced pharmacological activities were studied in mice. Oral administration of the extract (40 mg/kg) significantly inhibited morphine-induced analgesic tolerance, withdrawal symptoms, hyperactivity, reverse tolerance, Dopamine receptor supersensitivity and apo-morphine-induced climbing behaviour in mice. The results of this study showed that, alcoholic extract of Bacopa monniera (BMA) exerted inhibitory effect against morphine-induced pharmacological effects, suggesting that the extract could be useful in the treatment of morphine toxicity.
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