Polycystic ovarian syndrome: temporal characterization of the induction and reversion process in an experimental model
2004
Salvetti, Natalia R.(National University of Litoral Faculty of Veterinary Sciences Department of Anatomy and Histology,National University of Litoral Faculty of Veterinary Sciences Center for Experimental Biology and Laboratory Animals) | Canal, Ana M.(National University of Litoral Faculty of Veterinary Sciences Department of Basic Pathology of the Faculty) | Gimeno, Eduardo J.(National University of La Plata Faculty of Veterinary Sciences Institute of Pathology) | Ortega, Hugo H.(National University of Litoral Faculty of Veterinary Sciences Department of Anatomy and Histology,National University of Litoral Faculty of Veterinary Sciences Center for Experimental Biology and Laboratory Animals)
Inglés. Numerous experimental models have been developed for the study of the polycystic ovarian syndrome in the rat. In the present study, the syndrome was induced by exposure to constant light. The process was evaluated during its induction and also during its reversion. The estral cycle was analyzed through the vaginal cytology; reproductive parameters were evaluated by mating, as well as the ovarian morphology. All the animals developed the syndrome after 13 weeks of permanent light. The histologic characteristics of the ovaries, at week 15, were similar to those observed in the polycystic ovarian syndrome in human and other species. After regression of the syndrome, there was not difference in any of the evaluated reproductive parameters, when compared with the control group.
Mostrar más [+] Menos [-]Portugués. Numerosos modelos experimentais têm sido desenvolvimos para o estudo da síndrome do ovário policístico em ratos. No presente estudo, a síndrome foi inducida por exposição à luz constante. O processo foi avaliado durante sua indução e inclusive durante sua reversão. O ciclo estral foi analisado através de citologia vaginal; parámetros reprodutivos foram avaliados por acasalamento, bem como a morfologia ovariana. Todos animais desenvolveram a síndrome depois de 13 semanas de luz permanente. As características histológicas dos ovários, na semana 15, foram similares àquelas observadas na síndrome do ovário policístico em humanos e outras espécies. Após a regressão da síndrome, não houve diferenta em nenhum dos parámetros reprodutivos avaliados, quando comparados com o grupo controle.
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