Relation between cell growth and phytosterols in cell cultures of Ginkgo biloba, 2: Effects of mevalonic acid metabolites
2008
Terada, T.(Tokyo Univ. (Japan)) | Kaneyuki, T. | Inoue, H. | Kamoda, S.
The relationships between metabolites formed by the mevalonic acid pathway and cell growth in suspension cell cultures of Ginkgo biloba were investigated. Treatment of zaragozic acid, a specific sterol synthesis inhibitor, reduced cell growth and beta-sitosterol production. Addition of beta-sitosterol restored cell growth. Treatment of compactin, a specific inhibitor of mevalonic acid synthesis, reduced both cell growth and beta-sitosterol production. The addition of mevalonic acid restored cell growth, although that of beta-sitosterol did not. Treatment of tunicamycin or chaetomellic acid sodium salt, inhibitors of the synthesis of modification proteins, caused a decrease in cell growth. These results indicate that beta-sitosterol is one of the indispensable factors for cell growth, while the other metabolites formed by the mevalonic acid pathway might participate in the cell growth.
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