Development of Rapid Analytical Method of Forbidden Medicines in Dietary Supplements Using LC-ESI-Tandem MS
2007
Kim, H.Y. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea) | Lee, H.M. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea), E-mail: [email protected] | Jang, Y.M. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea) | Joo, H.J. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea) | Jung, Y.H. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea) | Lee, M.S. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea) | Park, J.S. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea) | Lee, K.H. (Gyeongin Regional Korea Food and Drug Administration, Incheon, Republic of Korea)
A high-performance liquid chromatography-electrospray ionization (HPLC-ESI) tandem MS was developed for the rapid and simultaneous determination of forbidden medicines in dietary supplements. Thirteen medicinal components such as PDE-5 inhibitors and their analogues, and the newly identified dimethylsildenafil and xanthoanthrafil, were included in this study. After tentative standardization of molecular ions in both polarities using thirteen references on the mass spectrometer, with ESI-continuous infusion via the syringe pump method, the relative intensity of the ions present in the resulting spectra was quantitatively compared.
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