Effects of the Soybean Powder with Rich Aglycone Isoflavone on Lipid Metabolism and Antioxidative Activities in Hyperlipidemic Rats
2008
Lim, A.K. (Daegu Technopark Bio Industry Center, Daegu, Republic of Korea) | Jung, H.K. (Daegu Technopark Bio Industry Center, Daegu, Republic of Korea) | Hong, J.H. (Daegu Technopark Bio Industry Center, Daegu, Republic of Korea) | Oh, J.S. (Shinhwa Pharm Research Inst., Gyeongju, Republic of Korea) | Kwak, J.H. (Shinhwa Pharm Research Inst., Gyeongju, Republic of Korea) | Kim, Y.H. (Shinhwa Pharm Research Inst., Gyeongju, Republic of Korea) | Kim, D.I. (Daegu Technopark Bio Industry Center, Daegu, Republic of Korea), E-mail: crs3814@hanmail.net
This study was performed to evaluate the effects of soybean powder with rich aglycone isoflavone through bio-transformation on lipid metabolism and antioxidative activities in diet induced hyperlipidemic rats. The rats were randomly divided into four groups: NO (basal diet normal group), CO (high fat diet control group), BFF10 (soybean powder with rich aglycone isoflavone 10% group), and BFF20 (soybean powder with rich aglycone isoflavone 20% group). After 7 weeks of BFF10 or BFF20 diets consumption, the concentrations in serum triglyceride, total cholesterol, LDL-cholesterol, and atherogenic index ratios were significantly decreased in the BFF10 and BFF20 diets groups compared with those in the CO group. The activities of alanine amino transferase and aspartate amino transferase were significantly decreased in the BFF10 and BFF20 than those in the CO group. Thiobarbituric acid reactive substance levels of serum were decreased in BFF10 and BFF20 groups compared to that of the CO group. The super oxide dismutase activites were increased in BFF10 and BFF20 groups compared to that of the CO group.
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