ALIPHATIC AND ARYLALIPHATIC ETHERS OF 5,7-DIHALOGEN-8-HYDROXYQUINOLINES AND THEIR PERCHLORATES AS POTENTIAL NUTRITIVE AND ANTICOCCIDIAL REMEDIES | Алифатни и арилалифатни етери на 5,7-дихалоген-8-хидроксихинолини и техни перхлорати като потенциални нутритивни и антикокцидиини средства
2010
Pavlov, A., Thracian University, Stara Zagora (Bulgaria) | Georgieva, N., Thracian University, Stara Zagora (Bulgaria) | Yaneva, Z., Thracian University, Stara Zagora (Bulgaria) | Dospataliev, L., Thracian University, Stara Zagora (Bulgaria) | Kojnarski, V., Thracian University, Stara Zagora (Bulgaria)
The determination of the anticoccidial activity of eight newly synthesized derivatives of substituted 8-hydroxyquinolines was carried out with 21-day-old chicken broilers, Cornish х Plymouthrock breed. According to the obtained screening results, two of the newly synthesized compounds: ethyl 2-(5,7-dichloro-2-methylquinoline-8-yloxy)acetate /3.1/ and 5,7-dichloro-2-methyl-8-(4-nitrobenzyloxy) quinoline /3.3/, displayed anticoccidial activity and stimulated the livе weight increase of infected and healthy chickens, at 350 ppm draughts. The highest anticoccidial activity was shown for compound /3.1/ (anticoccidial index–ACI = 95.1), at the highest chicken survival percent (SP=100%), equal to that of the non-invaded chickens control group without the addition of the investigated compounds to their food. A high SP was also observed for compounds: 5,7-dichloro-2-methyl-8-(4-nitrobenzyloxy)quinoline /3.3/ 90 %, 5,7-dibromo-8-(4-nitrobenzyloxy)quinoline /3.4/ 80 % and for ethyl 2-(5,7-dibromoquinolin-8-yloxy)acetate perchlorate /3.7/ 80 %. The lowest anticoccidial activity (ACI = 32.4) was determined for ethyl 2-(5,7-dibromoquinoline-8-yloxy)butanoate perchlorate /3.8/.
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