PATHOMORFOLOGICAL CHANGES IN SOME GLANDS OF INTERNAL SECRETION IN PIGS AFTER IRRADIATION AT 3.0 AND 4.5 GY
2010
kecheva, R., Thracian University, Stara Zagora (Bulgaria) | Velev, V., Thracian University, Stara Zagora (Bulgaria) | Nikiforov, I., Thracian University, Stara Zagora (Bulgaria)
The exposure to ionized radiation always results in systemic structural and functional alterations whose extent depends on both the exposure dose and many other environmental factors. The pituitary-adrenal glands, pituitary-thyroid gland and pituitary-genital glands axes are parts of the endocrine system that is a central regulator of the normal functioning of the organisms and its performance under changed conditions such as exposure to radiation. The purpose of this study was to establish the morphological changes and to compare tissue alterations in pituitary gland as a central organ of the endocrine system, and structural alterations in adrenal glands – peripheral glands of internal secretion. The experiment was performed with 10 male pigs, crosses of Big White x Landrace at the age of 45 days, irradiated at 3.0 Gy and 4.5 Gy. During the necropsy, a gross anatomy evaluation of pituitary and adrenal glands was done. Specimens for histological examination were collected, fixed in 10% neutral formalin and stained with haematoxylin/eosin. It was shown that the pituitary gland had a higher morphological resistance to ionized radiation and that the changes in its parenchyma were nor consistent even after irradiation at 4.5 Gy. The dystrophic changes in the adrenal cortex were much more severe for both used doses and they were responsible for the altered function of these glands.
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