Dysmyelopoiesis in a cat with immune-mediated hemolytic anemia
2008
Yu, D.H. (Chonbuk National University, Jeonju, Republic of Korea) | Lee, J.H. (Chonbuk National University, Jeonju, Republic of Korea) | Yoon, J.S. (Chonbuk National University, Jeonju, Republic of Korea) | Li, Ying-Hua (Chonbuk National University, Jeonju, Republic of Korea) | Lee, M.J. (Chonbuk National University, Jeonju, Republic of Korea) | Park, J.H. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: jpark@chonbuk.ac.kr
A 3-year-old spayed female Persian feline with non regenerative anemia showed persistent autoagglutination in EDTA anticoagulated blood. Primary immune-mediated hemolytic anemia (IMHA) was suspected and the underlying causes for IMHA were excluded by radiologic, sonographic, serologic and molecular studies. Cytologic examination of the bone marrow revealed that dysmyelopoiesis and dysplastic changes were prominent in the erythroid cells. These changes included asynchronous maturation of the nucleus and cytoplasm, binucleation, trinucleation, fragmented or lobulated nuclei and multilineages. Mild dysgranulopoiesis and dysmegakaryocytopoiesis were also detected including pseudo Pelger-Huet anomalies, giant band neutrophils, asynchronous maturation of the nucleus and cytoplasm in granulopoiesis and large hypolobulated forms as well as dwarf megakaryocytes in megakaryocy-topoiesis. Myelodysplastic syndrome and congenital dysmyelopoiesis was ruled out by the low number of blast cells. Finally, secondary dysmyelopoiesis associated with IMHA was diagnosed and immuno-suppressive treatment was successfully responsive.
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