A case of transitional carcinoma in the nasal cavity of a dog
2008
Kang, H.J. (Cheju National University, Jeju, Republic of Korea) | Kang, S.C. (Chemon Inc., Yongin, Republic of Korea) | Jung, J.Y. (Cheju National University, Jeju, Republic of Korea) | Jo, S.H. (Cheju National University, Jeju, Republic of Korea) | Roh, I.S. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Lee, J.M. (Cheju National University, Jeju, Republic of Korea) | Cheong, J.T. (Cheju National University, Jeju, Republic of Korea) | Kim, J.H. (Cheju National University, Jeju, Republic of Korea) | An, M.C. (Halla Pet Hospital, Jeju, Republic of Korea) | Bae, J.H. (Cheju National University, Jeju, Republic of Korea) | Kim, J.H. (Cheju National University, Jeju, Republic of Korea), E-mail: kimjhoon@cheju.ac.kr
A 10-year-old female Yorkshire terrier with the clinical signs of nasal swelling, epistaxis and nasal discharge was presented to the Veterinary Teaching Hospital in the Cheju National University. Abnormal nasal mass detected in physical examination and radiographic findings. After surgical excision, the sample of nasal mass was referred to Pathology Department of Veterinary Medicine. Grossly, the mass was soft, friable, and 2.5 × 4 cm in size. Histopathologically, the mass was composed of medium-sized non-keratinizing columnar to polyhedral cells arranged in anastomosing ribbon and large nest. It has complex in-folding of thick epithelial layers separated by fibrovascular septa. Tumor cells showed characteristic palisading arrangement of columnar cells, and perpendicularly distributed to the basement membrane. The cells had pale basophilic cytoplasm, oval nucleus and one or more nucleoli, and indistinct cellular border. Many tumor cell emboli were presented in lymphatics. Immunohistochemistry revealed that tumor cells were cytokeratic (CK) 19 and CK clone MNF116 positive and but CK7 and CK high molecular weight negative. Based on the gross, histopathologic, and immunohistochemical findings, the mass was diagnosed as transitional carcinoma in nasal cavity. In our best knowledge, this is the first report of transitional carcinoma originated from transitional zone of canine nasal cavity in Korea.
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