The effect of Bu-Zhong-Yi-Qi-Tang on ultraviolet B-induced skin damages in mouse
2009
Kim, J.S., Chonnam National University, Gwangju, Republic of Korea | Lee, H.J., Korea Institute of Radiological and Medical Science, Seoul, Republic of Korea | Song, M.S., Chonnam National University, Gwangju, Republic of Korea | Seo, H.S., Chonnam National University, Gwangju, Republic of Korea | Moon, C.J., Chonnam National University, Gwangju, Republic of Korea | Kim, J.C., Chonnam National University, Gwangju, Republic of Korea | Bae, C.S., Chonnam National University, Gwangju, Republic of Korea | Jo, S.K., Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea | Kim, S.H., Chonnam National University, Gwangju, Republic of Korea
The effect of Bu-Zhong-Yi-Qi-Tan (BZYQT) on the changes of ultraviolet (UV) light B radiation-induced apoptotic sunburn cell (SBC) and epidermal ATPase-positive dendritic cell (DC) in SKH1-hr or ICR mouse were investigated. The mice were treated with UVB (200 mj/㎠) and were sacrificed 24 h later. BZYQT (50 mg/kg of body weight) or vehicle (saline) was given i.p. at 36 and 12 h before irradiation, and 30 min after irradiation or BZYQT cream (0.2%) or cream base (vehicle) was topically treated at 24 h and 15 min before irradiation, and immediately after irradiation. The skin of SKH1-hr mouse prepared from the back of untreated mice exhibited about 0.3 SBC/cm length of epidermis, and 24 h after UV irradiation, the applied areas show an increased number of SBCs. But the frequency of UVB-induced SBC formation was reduced by intraperitoneal injection of BZYQT extract (p less than 0.01). The numbers of DC in normal ICR mouse were 628.00 ± 51.56 or 663.20 ± 62.58 per ㎟ of ear epidermis. By 1 day after UVB treatment, the number of ATPase-positive cells/㎟ were decreased by 39.0% or 27.1% in i.p. or topical application group with vehicle. Treatment of BZYQT was associated with increase of 33.9% in i.p. group (p less than 0.05) or 2.7% in topical application group in the number of ATPase positive cells compared with the irradiation control group. The results presented herein that BZYQT administration could reduce the extent of skin damages produced by UVB.
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