Impact of guava, Psidium guajava leaf powder and ethanol extract as hypolipidemic agents
2011
Taha, F.T. | El saadany, S.S. | Aboeyta, A.M. | El saed, H.M.
The lipid lowering effect of guava leaf powder and ethanol extract was carried out as hypolipidemic using Albino rats fed on high fat diet supplemented with cholesterol and cholic acid 1 % and 0.25 % respectively. The data were compared with rats fed on standard diet (Negative control). Induced hypolipidemia resulted in the elevation of serum levels of TC, TG, TL, LDL-C, VLDL, risk ratio, atherogenic index and TG / HDL-C ratio and lowered serum level of high-density lipoprotein cholesterol (HDL-C), chylomicronaemia ratio and HDL / PC ratio. Also feeding on high fat diet was accompanied with impaired liver and kidney functions. Administration of guava powder and its ethanol extract significantly lowered TC, TG, TL, LDL-C, VLDL-C, risk ratio, atherogenic index and TG / HDL-C ratio and increased the serum level of HDL-C, chylomicronaemia ratio and HDL / PC ratio. Furthermore, the impaired liver and kidney functions of rats administrated guava leaf (powder or ethanol extract) were recovered and nearly reached levels similar to that of the negative control.
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