Comparison of tuberculin skin test with Interferon-γ assay for the diagnosis of bovine tuberculosis in Korean cattle
2011
Shin, S.W., Seoul National University, Seoul, Republic of Korea | Shin, M.K., Seoul National University, Seoul, Republic of Korea | Cha, S.B., Seoul National University, Seoul, Republic of Korea | Woo, J.T., Gyeonggido Veterinary Service, Suwon, Republic of Korea | Lee, S.M., Incheon Metropolitan City Institute of Health and Environment, Incheon, Republic of Korea | Ku, B.K., Animal, Plant and Fisheries Quarantine and Inspection Agency, Anyang, Republic of Korea | Cho, Y.S., Animal, Plant and Fisheries Quarantine and Inspection Agency, Anyang, Republic of Korea | Jung, S.C., Animal, Plant and Fisheries Quarantine and Inspection Agency, Anyang, Republic of Korea | Yoo, H.S., Seoul National University, Seoul, Republic of Korea
Bovine tuberculosis (bTB), caused primarily by Mycobacterium bovis, continues to exert an economic loss, even in countries with active control measures, and is one of zoonotic diseases enable to be transmitted to human. The control and eradication of bTB are mainly based on a test and slaughter policy and/or abattoir surveillance. Various factors including limitation of diagnostic tests have been considered as major constraints to eradication. Single intradermal test (SIT) is the official diagnostic test. New diagnostic methods are needed to be developed, because of limitations of the test. In the present study SIT was compared with single intradermal comparative cervical test (SICCT) and interferon (IFN)-γ assay. There was very low correlation between SIT and SICCT. However, high correlation was shown between SIT and IFN-γ assay while no correlation was observed between SICCT and IFN-γ assay. Therefore, our results suggest the possibility of replacement of SIT with IFN-γ assay for the diagnosis of bovine tuberculosis.
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