Evaluation of humoral response and protective efficacy of two inactivated vaccines against bluetongue virus after vaccination of goats
2011
Zientara , Stephan (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Bréard , Emmanuel (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Belbis , Guillaume (Ecole Nationale Vetérinaire d'Alfort, Maisons-Alfort(FR). Pathologie du Bétail) | Hamers , C (Merial France(FR). Labo/service de l'auteur) | Moulin , V. (Intervet/Schering-Plough Animal Health(NL). Labo/service de l'auteur) | Lilin , Thomas (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Moreau , Francis (Ecole Nationale Vetérinaire d'Alfort, Maisons-Alfort(FR). centre de recherche biomedicales) | Millemann , Yves (Ecole Nationale Vetérinaire d'Alfort, Maisons-Alfort(FR). Pathologie du Bétail) | Montange , C. (Merial France(FR). Labo/service de l'auteur) | Sailleau , Corinne (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Durand , Benoit (Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail, Maisons-Alfort(France). Unité EPI) | DESPRAT , alexandra (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Viarouge , Cyril (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Hoffmann , B. (Institut fur virusdiagnstik, Greifwald-insel Riems(DE). Labo/service de l'auteur) | de Smit , H. (Intervet/Schering-Plough Animal Health(NL). Labo/service de l'auteur) | Goutebroze , S. (Merial France(FR). Labo/service de l'auteur) | Hudelet , P. (Merial France(FR). Labo/service de l'auteur)
Bluetongue serotype 8 has become a major animal health issue in the European Union and the Europeanmember States have agreed on a vaccination strategy, which involves only inactivated vaccines. Inthis study, the efficacy of two inactivated vaccines against bluetongue virus serotype 8 (BTV-8) used inEurope since 2008, BTVPUR ALSAP® 8 (MERIAL) and BOVILIS® BTV8 (Intervet/SP-AH), was evaluated ingoats immunized and challenged with BTV-8 field isolates under experimental conditions. Serological,virological and clinical examinations were conducted before and after challenge. Three groups of 10 goatseach (groups A, B and C) were randomly constituted and 2 groups (A and C) were subcutaneously vaccinatedtwice with one dose of the two commercial vaccines BTVPUR ALSAP 8 (group A) or BOVILIS BTV8(group C) respectively. Animals of the groups A, C and B (B: controls) were challenged with a virulentinoculum containing BTV-8. During the experiment, it was found out that the BTV-8 challenge inoculumwas contaminated with another BTV serotype. However, results demonstrated that vaccination of goatswith two injections of BTVPUR ALSAP 8 or BOVILIS BTV8 provided a significant clinical protection againsta BTV-8 challenge and completely prevented BTV-8 viraemia in all vaccinated animals. Qualitative datashowed no difference in the kinetics and levels of the humoral response induced by these two inactivatedvaccines.
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