Adminitration of rhIL-2 upregulates HGF in the cirrhotic liver of partial hepatechtomized rats
2013
Jeon, M.A., Soonchunhyang university, Asan, Repulic of korea | Kwon, H.J., Soonchunhyang university, Asan, Repulic of korea | Kim, Y.H., Soonchunhyang university, Asan, Repulic of korea | Han, K.I., Soonchunhyang university, Asan, Repulic of korea | Nam, K.W., Soonchunhyang university, Asan, Repulic of korea | Baik, Y.J., BMI Korea Company, Asan, Republic of Korea | Lee, S.H., BMI Korea Company, Asan, Republic of Korea | Kim, W.J., Soonchunhyang university, Asan, Repulic of korea | Han, M.D., Soonchunhyang university, Asan, Repulic of korea
Liver regeneration is a process involving highly organized and ordered tissue growth triggered by the loss liver tissue. This process has remained a fascinating topic in medicine. In this study, we examined the effects of recombinant human interleukin-2 in rats under cirrhotic conditions. thirty rats were divided into three groups, and liver cirrhosis was induced by injecting diethylnitrosamine for 2 weeks and CCl4 for 8 weeks. After induction of cirrhosis, rhIL2 was injected daily into their tail vein for three days and then hepatocyte growth factor , immunocytes in the blood, and TNF-a production were analyzed .
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