Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
Taghreed EL-Sayed | Asmaa Aboelnaga | Mohamed Hagar
Benzoic acid and o-phenylenediamine efficiently reacted under the green solvent-free Ball Milling method. Several reaction parameters were investigated such as rotation frequency: milling balls weight and milling time. The optimum reaction condition was milling with 56.6 g weight of balls at 20 Hz frequency for one hour milling time. The study was extended for synthesis of a series of benzimidazol-2-one or benzimidazol-2-thione using different aldehydes: carboxylic acids: urea: thiourea or ammonium thiocyanate with o-phenylenediamine. Moreover: the alkylation of benzimidazolone or benzimidazolthione using ethyl chloroacetate was also studied.
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