Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
2021
Joseph Dowsett | Egil Ferkingstad | Line Jee Hartmann Rasmussen | Lise Wegner Thørner | Magnús K. Magnússon | Karen Sugden | Gudmar Thorleifsson | Mike Frigge | Kristoffer Sølvsten Burgdorf | Sisse Rye Ostrowski | Erik Sørensen | Christian Erikstrup | Ole Birger Pedersen | Thomas Folkmann Hansen | Karina Banasik | Søren Brunak | DBDS Genomic Consortium | Vinicius Tragante | Sigrun Helga Lund | Lilja Stefansdottir | Bjarni Gunnarson | Richie Poulton | Louise Arseneault | Avshalom Caspi | Terrie E. Moffitt | Daníel Gudbjartsson | Jesper Eugen-Olsen | Hreinn Stefánsson | Kári Stefánsson | Henrik Ullum
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker.
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