SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
2022
Christopher J. Neufeldt | Berati Cerikan | Mirko Cortese | Jamie Frankish | Ji-Young Lee | Agnieszka Plociennikowska | Florian Heigwer | Vibhu Prasad | Sebastian Joecks | Sandy S. Burkart | David Y. Zander | Baskaran Subramanian | Rayomand Gimi | Seetharamaiyer Padmanabhan | Radhakrishnan Iyer | Mathieu Gendarme | Bachir El Debs | Niels Halama | Uta Merle | Michael Boutros | Marco Binder | Ralf Bartenschlager
Neufeldt et al. evaluate transcriptional and cytokine secretion profiles of cells and patient sera following SARS-CoV-2 infection and detect distinct upregulation of inflammatory cytokines. They also demonstrate that this upregulation is mediated by cGAS-STING and NF-κB signalling, which could provide a potential avenue for the development of future therapies against SARS-CoV-2.
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