Regulatory hyperparathyroidism in a pig breed with vitamin D dependency rickets [swine, porcine parathyroid hormone, (PTH), plasma, hereditary vitamin D dependency rickets, VDDR, metabolic defect, kidney]
1979
Wilke, R. | Harmeyer, J. | Grabe, C. von | Hehrmann, R. | Hesch, R.D. (Medizinische Hochschule Hannover (Germany, F.R.). Section of Clinical Endocrinology)
A radioimmunossay for porcine parathyroid hormone has been developed and applied to measure immunoreactive parathyroid hormone (PTH) in plasma of pigs with hereditary vitamin D dependency rickets (VDDR) (pseudovitamin D deficiency rickets). Levels of 25-hydroxycholecalciferol (25-(OH)-D3) in plasma were measured by a protein binding assay. Both plasma concentrations of PTH and 25-(OH)-D3 showed an approximately 4-fold increase compared to normal pigs. PTH levels increased with duration of the disease. Daily dosing of the animals with 1-4 micrograms of 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3) reduced PTH concentrations and resulted in clinical healing. Iv administration of 10 micrograms of 25-(OH)-D3/ day did not alter PTH concentrations nor the clinical symptoms. The results suggest that these animals suffer from regulatory hyperparathyroidism. The metabolic defect could be due to a failure of the kidney to convert 25-(OH)-D3 to 1,25-(OH)2-D3.
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