Vaccination of sheep with cell culture grown orf virus [contagious ecthyma; contagious pustular dermatitis; poxvirus; scabby mouth]
1990
Pye, D. (Commonwealth Serum Lab., Parkville (Australia))
Orf virus, derived from contagious pustular dermatitis (scabby mouth) lesions in sheep, was adapted to cell culture and subsequently evaluated as a potential vaccine for sheep. In contrast to the traditional vaccine virus prepared from the infected scabs of lesions, a recent field isolate has yielded a cell culture-adapted virus preparation that readily infects sheep, produces large lesions, detectable antibody and protects against challenge. This isolate is distinct from the traditional vaccine strain on the basis of restriction enzyme analysis but provides cross-protection in sheep immunisation and challenge studies. These results demonstrate that a cell culture produced scabby mouth vaccine is feasible.
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