Chromosomal position effects and the modulation of transgene expression [livestock; review]. [Symposium paper]
1994
Clark, A.J. | Wallace, R. | Whitelaw, C.B.A. | Yull, F. (AFRC Roslin Inst., Midlothian, Scotland (United Kingdom)) | Bissinger, P. (Ruakura Research Inst., Hamilton (New Zealand)) | Bullock, D.W. | Damak, S. (Lincoln Univ., Canterbury (New Zealand). Centre for Molecular Biology)
Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.
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