Immunohistochemistry of the progressive and regressive stages of bovine papillomatosis
1997
Emhmad Abdouslam, O. | Levkut, M. | Levkutova, M. | Revajova, V. | Ondrejka, R. | Benisek, Z. (Univerzita Veterinarskeho Lekarstva, Kosice (Slovak Republic))
The progressive and regressive stages of fibropapilloma in their unusual papillomatous formation in calves are described. Papillated hyperplasia of the epidermis and high mitotic activity in stratum basale characterized the progressive stage. The regressive stage (120 days later) showed infiltration of dermal papillary layer by mononuclear cells (CD3+ cells and macrophages), a thin stratum spinosum without long rete ridges, and massive hyalinization of collagen in the dermis. Several basal cells in the mitotic cycle were immunohistochemically positive for papillomavirus. Immunohistochemically, papillomavirus was demonstrated in these lesions with the higher numbers of virus positive cells in the progressive stage. Some cells in the stratum spinosum showed both cytoplasmic- and nuclear-staining for the virus, which implies the budding of the virion into the cytoplasm in these layers.
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