New reagents for fluoromethylene transfer chemistry
Veliks Veliks, Jānis Janis | Melngaile Melngaile, Renāte Renate | Sperga Sperga, Artūrs Arturs | Kazia, Armands
Chemistry is all around us. All visible matter is made of atoms and molecules. The biological processes taking place in a living organism are complex cascades of chemical reactions catalysed by enzymes. Since ancient times, humans have tried to transform matter – smelting ore into metals, converting fat and oils into soap, making fermentation to rise bread and produce beverages. The modern chemical science has not only revealed the molecular bases of all these processes known for millennia but also has created methods and reagents to make new, previously inexistent compounds, to develop drugs against previously incurable diseases as well as specialty materials that make our modern life possible. The same as surgeon needs all kinds of tools, like scalpels, forceps, and scissors, a chemist needs reagents to manipulate molecules. New compounds are created in chemical reactions requiring special reagents dedicated to do a certain task by converting a starting material into a desired product in a predictable manner. Our research group deals with the development of methods and reagents for the synthesis of a special class of chemicals – organofluorine compounds. Fluorine is an extremely rare element in living organisms. A completely different picture reveals when looking at the chemical structures of known pharmaceutical drugs. Almost 25% of currently available drugs in the market contain at least one fluorine atom in their chemical structure which belongs to a class of organofluorine compounds.
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