Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment
2014
Vignet, Caroline | Devier, Marie Helene | Le Menach, Karyn | Lyphout, Laura | Potier, Jérémy | Cachot, Jérôme | Budzinski, Hélène | Bégout, Marie-Laure | Cousin, Xavier | Laboratoire d'Écotoxicologie (LEX) ; Biogéochimie et Ecotoxicologie (BE) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Environnements et Paléoenvironnements OCéaniques (EPOC) ; Observatoire aquitain des sciences de l'univers (OASU) ; Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) | Laboratoire Ressources Halieutiques (LRH) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) | ANR ConPhyPop (2009-002) ; CPER A2E ; European Regional Development Fund ; Region Poitou-Charentes ; Ifremer | ANR-09-CESA-0002,CONPHYPOP,Contamination et physiologie des poissons aux polluants(2009)
A natural sediment spiked with three individual polycyclic aromatic hydrocarbons (PAHs; pyrene, phenanthrene and benzo[a]pyrene) was used to expose zebrafish embryos and larvae during 4 days. The total PAH concentration was 4.4 μg g−1 which is in the range found in sediment from contaminated areas. Quantification of metabolites in the larvae after exposure confirmed the actual contamination of the larvae and indicated an active metabolism specially for pyrene and benzo[a]pyrene. After a transfer in a clean medium, the larvae were reared to adulthood and valuated for survival, growth, reproduction, and behavior. Measured endpoints revealed a late disruption of growth (appearing at 5 months) and a trend toward a lower reproductive ability. Adults of embryos exposed to sediment spiked with PAHs displayed lethargic and/or anxiety-like behaviors. This latter behavior was also identified in offspring at larval stage. All together, these effects could have detrimental consequences on fish performances and contribution to recruitment.
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