Effect of bisphenol A on formation and process of alergic reaction - review
2023
Bažány, Denis | Greifová, Hana | Štefunková, Nikola | Jambor, Tomáš | Tokárová, Katarína | Lukáč, Norbert
One of the possible immunomodulatory effects of BPA is alterating the allergy process and asthma. The growth in the prevalence of asthma around the world roughly corresponds with the rise in the widespread usage of certain chemicals. Despite the fact that asthma is a complicated and varied condition brought on by exposure to a variety of environmental factors and genetic predispositions, many classes of chemicals that are frequently present in the surrounding environment and are linked to endocrine disruption have recently been linked to the disease's pathogenesis. BPA is endocrine disrupting chemical compound made up of two phenol rings joined by a methyl bridge and two methyl functional groups adhered to the bridge. BPA is ingested by humans, inhaled via home dust, and exposed through the skin. An allergy is an aberrant immunological reaction to an antigen, such as a protein or allergen. An ingested or breathed allergen encounters the epithelium as its initial barrier. The inflammatory condition and increased permeability of the epithelial barrier are associated with allergic inflammatory disorders, and this suggests that the epithelium barrier is more sensitive to allergen sensitization. The existing literature and scientific publications do not adequately address the direct influence of bisphenols on the development and influence of the allergic process. Multiple authors discuss how bisphenol affects specific allergic response components. We may conclude that exposure to bisphenol A alters the allergic response based on the findings of the studies and the analysis of the literature.
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