Diastereoselective access to substituted oxetanes via hydrosilylation–iodocyclisation of homopropargylic alcohols
2022
Roberts, Dean D. | McLaughlin, Mark G.
The regio and stereoselective hydrosilylation of a variety of homopropargylic alcohols and their derivatives is described. The reaction is tolerant to a variety of sterically and electronically varied substrates, affording only the E-vinyl silane as a sole regioisomer. The application of the resultant vinyl silanes towards the diastereoselective synthesis of tetrasubstituted oxetanes is demonstrated.
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