Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2

Devine, Michael J.; Lewis, Patrick A.

Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2

2008

Devine, Michael J. | Lewis, Patrick A.

The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in α-synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson's disease, characterized by variable pathology including either α-synuclein or tau deposition, it has been suggested that LRRK2 functions as an upstream regulator of Parkinson's disease pathogenesis. This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, α-synuclein and tau.

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Palabras clave de AGROVOC

biochemistry genetics humans metabolism models models mutation mutation pathogenesis physiology physiopathology tau

Información bibliográfica

Publicado en

FEBS journal

Volumen 275 Edición 23 Paginación 5748 - 5757 ISSN 1742-464X

Editorial

Oxford, UK : Blackwell Publishing Ltd

Otras materias

Parkinson disease; Lewy bodies; Dementia; Tau proteins; Dementia; Roco protein; Α-synuclein; Lewy bodies; Paired helical filament; Neurofibrillary tangles; Neurofibrillary tangles; Protein serine-threonine kinases; Parkinson disease; Lrrk2; Biological; Snca; Mapt; Alpha-synuclein

Idioma

Inglés

Tipo

Journal Article; Text

En AGRIS desde: 2024-02-27

Formato: MODS

Proveedor de Datos

Este registro bibliográfico ha sido proporcionado por National Agricultural Library

Descubra la colección de este proveedor de datos en AGRIS

Enlaces

DOI http://dx.doi.org/10.1111/j.1742-4658.2008.06707.x

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