Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2

Devine, Michael J.; Lewis, Patrick A.

Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2

2008

Devine, Michael J. | Lewis, Patrick A.

The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in α-synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson's disease, characterized by variable pathology including either α-synuclein or tau deposition, it has been suggested that LRRK2 functions as an upstream regulator of Parkinson's disease pathogenesis. This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, α-synuclein and tau.

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Mots clés AGROVOC

biochemistry genetics humans metabolism models models mutation mutation pathogenesis physiology physiopathology tau

Informations bibliographiques

Publié dans

FEBS journal

Volume 275 Numéro 23 Pagination 5748 - 5757 ISSN 1742-464X

Editeur

Oxford, UK : Blackwell Publishing Ltd

D'autres materias

Parkinson disease; Lewy bodies; Dementia; Tau proteins; Dementia; Roco protein; Α-synuclein; Lewy bodies; Paired helical filament; Neurofibrillary tangles; Neurofibrillary tangles; Protein serine-threonine kinases; Parkinson disease; Lrrk2; Biological; Snca; Mapt; Alpha-synuclein

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-27

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI http://dx.doi.org/10.1111/j.1742-4658.2008.06707.x

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