Potential CRF₁R PET imaging agents: 1-Fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones
2013
Denhart, Derek J. | Zuev, Dmitry | Ditta, Jonathan L. | Hartz, Richard A. | Ahuja, Vijay T. | Mattson, Ronald J. | Huang, Hong | Mattson, Gail K. | Zueva, Larisa | Nielsen, Julia M. | Kozlowski, Edward S. | Lodge, Nicholas J. | Bronson, Joanne J. | Macor, John E.
A series of pyrazinones were prepared and evaluated as potential CRF₁R PET imaging agents. Optimization of their CRF₁R binding potencies and octanol–phosphate buffer phase distribution coefficients are discussed herein.
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