In vivo pretreatment of Eudrilus eugeniae powder attenuates β-adrenoceptor toxicity mediated by isoproterenol in rat model
2016
Anitha, Jaganathan | Murugan, Kadarkarai | Higuchi, Akon | Alarfaj, Abdullah A. | Munusamy, Murugan A. | Benelli, Giovanni
The present study was designed to discover the potential cardioprotective function of earthworm powder (EWP) extracted from Eudrilus eugeniae on isoproterenol (ISO)-induced myocardial infarction in male Wistar rats. The rats were divided into four groups, with six rats in each group. Certain rats were pretreated with EWP (200mg/kgbwt) (Group III), and a myocardial infarction was then induced by subcutaneous injection of ISO (85mg/kgbwt) (Group II). Oral pretreatment of 200mg/kgbwt of EWP for 28days significantly (p>0.05) improved the blood profile levels, including (a) the lipid profile of total cholesterol (TC), free fatty acids (FFA), and triglycerides (TG); (b) low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), and protein; and (c) A/G ratio, glucose and uric acid levels. The electrophoretic pattern of elevated lactose dehydrogenase (LDH) levels was recovered by EWP treatment as evidenced by comparison with ISO-induced rats with cardiac damage. The above results indicate that EWP (200mg/kgbwt) provides a cardioprotective effect by attenuating the blood profile, lipid profile, biochemical levels, and LDH patterns in rats that experienced an ISO-induced myocardial infarction.
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