Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin
2017
Akolade, Jubril Olayinka | Oloyede, Hussein Oyelola B. | Onyenekwe, Paul C.
Low bioavailability, poor aqueous stability and lack of appropriate delivery systems delimit the chemotherapeutic effect of curcumin. In this study, curcumin was encapsulated in chitosan-based polyelectrolyte complexes and its antidiabetic activities were assessed using in vitro α-amylase inhibitory assay and in vivo antihyperglycaemic effect in alloxan-induced rats. Microscopic examination showed nanoformulations (<50nm) of curcumin loaded in chitosan-alginate complex. Improved encapsulation efficiency (64–76%), loading capacity (20–26%) and yield (50–72%) were achieved. Complexation of chitosan with alginate reduced loss of curcumin by 20% and extended mean release time by 40min in simulated gastric fluid. Time dependent study showed that the α-amylase inhibitory activity of curcumin was enhanced via nanoencapsulation. Oral administration of sub-therapeutic dosage of curcumin (50mg/kg b.wt.) nanoencapsulated in chitosan-based complexes caused significant reduction in hyperglycaemia within 7days of treatment. Overall, chemotherapeutic effectiveness of curcumin was enhanced via nanoencapsulation in chitosan-based polyelectrolyte complexes.
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