A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones
2015
Zhu, Yuelu | Li, Cheng | Zhang, Jidong | She, Mengyao | Sun, Wei | Wan, Kerou | Wang, Yaqi | Yin, Bin | Liu, Ping | Li, Jianli
A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl₃/I₂-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.
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