Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors
2015
Maldonado, Natalia | Castro, Bibiana | Berrio, Indira | Manjarrés, Miguel | Robledo, Carlos | Robledo, Jaime
Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections.A retrospective case–control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections.The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08–10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08–38.38).Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.
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