Synthesis and photophysical studies of a chlorin sterically designed to prevent self-aggregation
2013
de Assis, Francisco F. | de Souza, Juliana M. | Assis, Beatriz H.K. | Brocksom, Timothy J. | de Oliveira, Kleber T.
Synthesis and photophysical evaluations of a new non-aggregating chlorin derivative are described. A β-octa(carboxyethyl)porphyrin 3 was synthesized in 2 steps starting from pyrrole-3,4-dicarboxylic acid diethyl ester (2). The new chlorin derivative 6 was obtained through a 1,3-dipolar cycloaddition using benzyl azomethine ylide. Chlorin 6 presents a molecular scaffold in an “L” shape avoiding aggregation in solutions at 1–27 mM. Photophysical properties were measured, and indicate that this new compound can be considered a useful candidate for PDT studies.
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