Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum
2011
Zhang, Guojian | Sun, Shiwei | Zhu, Tianjiao | Lin, Zhenjian | Gu, Jingyan | Li, Dehai | Gu, Qianqun
Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H₁N₁) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay.
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