Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum

Zhang, Guojian; Sun, Shiwei; Zhu, Tianjiao; Lin, Zhenjian; Gu, Jingyan; Li, Dehai; Gu, Qianqun

Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum

2011

Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H₁N₁) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay.

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Mots clés AGROVOC

animals antiviral agents chemistry dogs emericella endophytes fermentation fungi microbiology nuclear magnetic resonance spectroscopy pharmacology primulaceae

Informations bibliographiques

Publié dans

Phytochemistry

Volume 72 Numéro 11 Pagination 1436 - 1442 ISSN 0031-9422

Editeur

Elsevier B.V.

D'autres materias

Drug effects; Cell line; Plant bark; Cytopathogenicity; Magnetic resonance spectroscopy; Isolation & purification; Molecular structure; Isoindoles; Biological products; Aegiceras corniculatum; Sesquiterpenes; Influenza a virus; H1n1 subtype

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI DOI http://dx.doi.org/10.1016/j.phytochem.2011.04.014

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